Re-industrialization is the integral part of the economic reconstruction since the Obama administration came into power and it marks the major transition and critical turn of U.S. economic policy after the financial crisis.The Chinese academia has shown great concern about the policy shift in the United States but researchers have different views on the U.S. re-industrialization. There are still some divergences about whether the policy adjustment in the United States is a temporary expedient to deal with the financial crisis or a strategic turn with a profound significance in Chinese academia. This is mainly because （1）most existing studies analyzed U.S. re-industrialization strategy from an economic perspective or are based on the plan and policies of the Obama administration and ignored the national strategic concerns behind it; （2）most existing studies analyzed the influences brought by the long-term de-industrialization on the United States only at the economic level and lack the overall grasp. In order to make up for the deficiencies in the existing studies，this paper makes a systematic exposition on the deep motivation and the decision logic of the policy adjustment in the United States through the introduction of the national security perspective. First， this paper begins with a survey of the logic and connotation of U.S. national security and the relationship between manufacturing and U.S. national security; Secondly， this paper systematically analyzes the challenges brought by the long-term de-industrialization upon U.S. national security from the four linked levels of economy，society，politics and ideology; Finally，this paper discusses the national security implications of U.S. re-industrialization strategy and its impact on China． This study reaches the following conclusions: （1）Safeguarding American leadership in the world is the main goal of U.S. national security strategy since the end of the Cold War. And national power is the force base to maintain American hegemonic position in the world; （2）It is the basic logic of U.S. national security that American national security is more like a cloak and the generalization of national security is just for pursuing its unreasonable national interests; （3）American power has been impaired systematically by the long-term de-industrialization as economic excessive virtualization，social differentiation and tensions，political polarization and ideological crisis of the American dream.This situation has brought comprehensive and structural challenges to the U.S. national security and has threatened American leadership in the world.So the U.S. government had to consider and deal with manufacturing problems from the national security level.And these are the deep-seated reasons for the Obama administration to push the re-industrialization strategy; （4）Far more than just an economic strategy， the re-industrialization is also a security strategy. It is the embodiment of the U.S. national security strategy adjustment. It contains the nature of strategic conflict and the meaning of strengthening trade protectionism to China; （5）Re-industrialization is not only a temporary expedient to deal with financial crisis ，but also a strategic turn with a profound significance. This is not to say that the U.S. government will achieve the goal of U.S. re-industrialization because planning to do it and the ability to do it are two entirely different things.