Based on the theory of ″triangle of change″ on interdisciplinary research advanced by Diana Rhoten and combined with the analysis of cases of interdisciplinary research at American universities, this study focuses on the exploration of the ″systemic implementation″ acting as the core of university governance structure. This study concludes that a highly-productive, and highly-efficient interdisciplinary research system has the following characteristics: first and foremost, it should gain the strong support and motivation from the central management system of the university; secondly, it should build up a well-functioning rectangular management structure within traditional academic organizations such as colleges or departments; thirdly, it should establish an internal dynamic organization system characterized not only by the production of knowledge with the integration of discipline paradigms and team collaboration but also by network service management. Moreover, the implementation of interdisciplinary research system should also generate sustainable driving forces of development, cultivate an internal environment constituted with disciplinary ecological environment, institutional environment and cultural environment, and construct an external environment with continuous supplies of funds and professional instructions. The above conclusion may provide helpful inspiration and enlightenment for the interdisciplinary research at universities in China.